Innovation Detail

Innovation Description

The traditional knowledge holder has suggested treatment for fracture.
Disease symptoms: Swelling or bruising over a bone, deformity of a bone, pain in the injured area, inability to bear weight on the affected area.
Ingredients: 100 g root bark of Hadabhanga (Cissus quadrangularis L.), 50 g leaves of Talamuli (Curculigo orchioides Gaertn.), 50 g aerial root of Bar Pahar (Ficus benghalensis L.), 50 g root of Kuelekha (Hygrophila auriculata (Schumach.) Heine), 50 g roots of Gadgad (Coix lacryma-jobi L.), 50 g leaves of Pathar khol (Pueraria tuberosa (Roxb. ex Willd.) DC.), 50 g leaves of Lal ganja (Tagetes erecta L.), 50 g root of Baidanja (Mucuna pruriens (L.) DC.), 50 g bark of Sahada (Streblus asper Lour.), 50 g root of Sunsunia (Marsilea minuta L.), 50 g bark of Pankel (Ficus racemosa L.), 50 g root of Gandhalata (Cyperus rotundus L.), 50 g root of Mayur chul (Elephantopus scaber L.), 50 g root of Lathi buro (Ziziphus mauritiana Lam.), 50 g root of Kirkichi (Mimosa prainiana Gamble), 50 g root of Kain phul (Nymphaea alba L.), 50 g bark of Semel (Bombax ceiba L.), 50 g bark of Mahul (Madhuca longifolia var. latifolia (Roxb.) A.Chev.), 50 g bark of Aam (Mangifera indica L.), 50 ml Coconut water and 20 fruits of Golmarich (Piper nigrum L.).
Preparation: Collect, clean and crush all the plants together to prepare a paste.
Dosage/Application: Apply the prepared paste over the affected area and wrap a bandage over it.
Precaution: Avoid fish and tamarind.
Ingredients' availability: The plants are available in nearby places. Other ingredients are available in the local market. 


Suggested Reading(s):

Adhikari, S., Gurung, T. M., Koirala, A., Adhikari, B. R., Gurung, R., Basnet, S., & Parajuli, K. (2017). Study on fracture healing activity of ethnomedicinal plants in western Nepal. World Journal of Pharmacy and Pharmaceutical Sciences, 6(10), 93-102. 

Alamsyah, Y., Ilyas, S., & Putra, D. P. (2020). The mangiferin (Mangifera indica Linn) effect against the calcium degradation, bones resorption and ossification of Rattus novergicus of post-orthodontic treatment. Journal of International Dental and Medical Research, 13(2), 430-435. 

Chauhan, S., Sharma, A., Upadhyay, N. K., Singh, G., Lal, U. R., & Goyal, R. (2018). In-vitro osteoblast proliferation and in-vivo anti-osteoporotic activity of Bombax ceiba with quantification of Lupeol, gallic acid and ?-sitosterol by HPTLC and HPLC. BMC complementary and alternative medicine, 18(1), 233. 

Hardik, S., Jalak, K., Deepti, J., & Ghanashyam, P. (2014). Evaluation of bonton active granules for anti-osteoporotic activity in ovariectomized rat. World Journal of Pharmaceutical Sciences. 2(2): 181-187. 

Jiao, L., Cao, D. P., Qin, L. P., Han, T., Zhang, Q. Y., Zhu, Z., & Yan, F. (2009). Antiosteoporotic activity of phenolic compounds from Curculigo orchioides. Phytomedicine, 16(9), 874-881. 

Kum, C. J., Kim, E. Y., Kim, J. H., Lee, B., Min, J. H., Heo, J., ... & Jung, H. S. (2017). Cyperus rotundus L. extract suppresses RANKL-induced osteoclastogenesis through NFATc1/c-fos downregulation and prevent bone loss in OVX-induced osteoporosis rat. Journal of Ethnopharmacology, 205, 186-194. 

Lassila, H., Johns, N. P., O'Neil, C. K., Johns, J. R., Balk, J. L., & Witt-Enderby, P. A. (2014). Alternative options to manage menopausal symptoms with a focus on melatonin and osteoporosis. Clinical Pharmacology and Biopharmaceutics, 3 (115). doi:10.4172/2167- 065X.1000115. 

Muthusami, S., Senthilkumar, K., Vignesh, C., Ilangovan, R., Stanley, J., Selvamurugan, N., & Srinivasan, N. (2011). Effects of Cissus quadrangularis on the proliferation, differentiation and matrix mineralization of human osteoblast like SaOS?2 cells. Journal of Cellular Biochemistry, 112(4), 1035-1045. 

Narayanan, G., Prabhu, K., Rao, M. R., Kannan, K., Sundaram, R. L., Dinakar, S., & Vijayalakshmi, N. (2019). Gas chromatography-mass spectrometry analysis of one Ayurvedic medicine, Drakshadi Kashayam. Drug Invent Today, 11, 2652-6. 
Parvez, G. M. (2016). Pharmacological activities of mango (Mangifera indica): A review. Journal of Pharmacognosy and Phytochemistry, 5(3), 1-7. 

Satpathy, S., Patra, A., Hussain, M. D., Kazi, M., Aldughaim, M. S., & Ahirwar, B. (2020). Antioxidant enriched fraction from Pueraria tuberosa alleviates ovariectomized-induced osteoporosis in rats, and inhibits growth of breast and ovarian cancer cell lines in vitro. bioRxiv. 

Shiksharthi, A. R., & Mittal, S. (2011). Ficus racemosa: phytochemistry, traditional uses and pharmacological properties: a review. International Journal of Recent Advances in Pharmaceutical Research, 4, 6-15. 

Yang, X., Zheng, H., Liu, Y., Hao, D., He, B., & Kong, L. (2020). Puerarin for OVX-Induced Postmenopausal Osteoporosis in Murine Model: Systematic Review and Meta-Analysis. Current Stem Cell Research & Therapy, 15(1), 37-42.