Innovation Description
The traditional knowledge holder has suggested treatment for skin disorders
Disease symptoms: Itching, rashes, redness.
Ingredients: 50 g each of, fruits and bark of Harde (Terminalia chebula Retz.), fruits and bark of
Aawla (Phyllanthus
emblica L.), fruits and bark of
Baheda (Terminalia
bellirica (Gaertn.) Roxb.), Leaves and
bark of Ardusi (Justicia adhatoda L.), Leaves and bark of Jethimadh (Glycyrrhiza glabra L.), Dry rhizome of Aadu (Zingiber
officinale Roscoe), Roots of
Piprimul (Piper longum L.), Rhizome of
Haldar (Curcuma longa L.), Rhizome of
Majith (Rubia
cordifolia L.), Rhizome of
Nagarmoth (Cyperus
rotundus L.), Bark of Kada (Holarrhena
pubescens Wall. ex G.Don), Bark of Galo (Tinospora cordifolia (Willd.)
Hook.f. & Thomson), Leaves of Kadu Kariyatu (Andrographis
paniculata (Burm.f.) Nees), Leaves of Bhoiringani
(Solanum virginianum L.), Bark
of Limdo (Azadirachta indica A. Juss.), Leaves of Dhamaso (Zygophyllum creticum (L.)
Christenh. & Byng), Leaves of Pitpapdo (Eugenia
indica (Wight) Chithra), Leaves of Parvad (Trichosanthes
dioica Roxb.), Leaves of Suva (Anethum graveolens L.), Leaves of Ashwagandha (Withania somnifera (L.)
Dunal), Leaves of Chitrak (Plumbago zeylanica L.), Leaves of Satavari (Asparagus racemosus Willd.), Leaves of Vavding (Embelia ribes Burm.f.), Leaves of Piplo (Ficus
religiosa L.), Leaves of Indrajav (Wrightia tinctoria (Roxb.)
R.Br.), Leaves of Bhrungraaj (Eclipta prostrata (L.) L.), Leaves of Devdaar (Cedrus
deodara (Roxb. ex D.Don) G.Don), Bark of Kher (Senegalia
catechu (L.f.) P.J.H.Hurter &
Mabb.), Bark of Chandan (Santalum album L.), Bark of Varun (Crataeva nurvala Buch. Ham.), Bark of Garmalo (Cassia fistula L.), Bark of Karanj (Millettia
pinnata (L.) Panigrahi), Roots of Atishanikala
(Aconitum heterophyllum Wall. ex Royle), Roots of Kadu (
Picrorhiza kurroa Royle ex Benth.).
Preparation: Dry and grind the plant parts to form a powder. Take 2-3 teaspoon powder and add 1 cup of water.
Dosage/Application: Consume the solution twice daily on an empty stomach till cure. Add little water into powder to form paste and applied on the affected parts.
Ingredients' availability: The plants are available in nearby places.
Suggested Reading(s):Abubakar, S., Ahmed, Q. U., Othman, A. S., & Omar, M. N. (2011). Bacteriostatic and bactericidal activity of the polar and non-polar extracts of
Andrographis paniculata against skin disease-causing pathogenic bacteria.
J Med Plant Res, 5, 7-14.
Asthana, J. G., Jain, S., Ashutosh, M., & Vijay Kanth, M. S. (2001). Evaluation of antileprosy herbal drug combinations and their combinations with dapsone.
INDIAN DRUGS-BOMBAY-, 38(2), 82-86.
Bandyopadhyay, U., Chatterjee, R. and Bandyopadhyay, R., (1998)
US Patent, 5: 730,986. Corresponding to Indian Patent 1100/Del/95.
Bhagavathula, N., Warner, R. L., DaSilva, M., McClintock, S. D., Barron, A., Aslam, M. N., ... & Varani, J. (2009). A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid?impaired hairless rat skin.
Wound repair and regeneration, 17(3), 360-366.
Bhagavathula, N., Warner, R. L., DaSilva, M., McClintock, S. D., Barron, A., Aslam, M. N., ... & Varani, J. (2009). A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid?impaired hairless rat skin.
Wound repair and regeneration, 17(3), 360-366.
Bhujbal, M. M. (1999). Patoladi Quath in the management of skin disorder.
Deerghayu, 58, 72-76.
British Pharmacopoeia, (1993) Vol. II, British Pharmacopoeia Commission, HMSO Publication Centre, London, 1096.
Chan, C. F., Huang, W. Y., Guo, H. Y., & Wang, B. R. (2014). Potent antioxidative and UVB protective effect of water extract of Eclipta prostrata L.
The Scientific World Journal, 2014.
Cheng, H. Y., Lin, T. C., Yu, K. H., Yang, C. M., & Lin, C. C. (2003). Antioxidant and free radical scavenging activities of
Terminalia chebula.
Biological and Pharmaceutical Bulletin, 26(9), 1331-1335.
Choo, B. K., Yoon, T., Cheon, M. S., Lee, H. W., Lee, A. Y., & Kim, H. K. (2009). Anti-inflammatory effects of
Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation.
Journal of ethnopharmacology,
121(1), 28-34.
Choudhary, G.P. (2008). Wound healing activity of the ethanol extract of
Terminalia bellerica Roxb. fruits.
Natural Product Radiance, 7(1), 19-21.
Dai, Y., Hou, L. F., Chan, Y. P., Cheng, L., & But, P. P. H. (2004). Inhibition of immediate allergic reactions by ethanol extract from
Plumbago zeylanica stems.
Biological and Pharmaceutical Bulletin,
27(3), 429-432.
Darji, V. C., Deshpande, S. S., & Bariya, A. H. (2012). Effects of methanolic extract of
Holarrhena antidysenterica bark against experimentally induced inflammatory bowel disease in rats.
Int Res J Pharm, 3(9), 152-4.
Dhanabal, S. P., Raj, B. A., Muruganantham, N., Praveen, T. K., & Raghu, P. S. (2012). Screening of Wrightia tinctoria leaves for antipsoriatic activity.
Hygeia-Journal for Drugs and Medicine,
4(1), 73-78.
Drabu, S., Khatri, S., & Babu, S. (2012). Neem: Healer of all ailments.
Research Journal of Pharmaceutical, Biological and Chemical Sciences,
3(1), 120-126.
Gerber, H. P., Dixit, V., & Ferrara, N. (1998). Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells.
Journal of biological chemistry, 273(21), 13313-13316.
Gottlieb, A. B. (2005). Psoriasis: emerging therapeutic strategies.
Nature reviews Drug discovery, 4(1), 19-34.
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008). Wound repair and regeneration.
Nature,
453(7193), 314-321.
Horváth, S., Komlódi, R., Perkecz, A., Pintér, E., Gyulai, R., & Kemény, Á. (2019). Methodological refinement of Aldara-induced psoriasiform dermatitis model in mice.
Scientific reports, 9(1), 1-8.
Hostettmann, K., & Marston, A. (1995). Chemistry and pharmacology of natural products (Vol. 548, pp. 326-327). Cambridge, UK:: Cambridge University Press.
Isaac, C., Paggiaro, A. O., Aldunate, J. L. C. B., Herson, M. R., Altran, S. C., Mônica Beatriz, M., & Ferreira, M. C. (2011). Role of keratinocytes in wound contraction: an impact assessment using a model of collagen matrix populated with fibroblasts.
Revista Brasileira de Cirurgia Plástica, 26(3), 402-406.
Jamadagni, P. S., Pawar, S. D., Jamadagni, S. B., Chougule, S., Gaidhani, S. N., & Murthy, S. N. (2017). Review of Holarrhena antidysenterica (L.) Wall. ex A. DC.: Pharmacognostic, pharmacological, and toxicological perspective.
Pharmacognosy Reviews, 11(22), 141.
Just, M. J., Recio, M. C., Giner, R. M., Cuéllar, M. J., Máñez, S., Bilia, A. R., & Ríos, J. L. (1998). Anti-inflammatory activity of unusual lupane saponins from
Bupleurum fruticescens.
Planta medica,
64(05), 404-407.
Kang, D., Li, B., Luo, L., Jiang, W., Lu, Q., Rong, M., & Lai, R. (2016). Curcumin shows an excellent therapeutic effect on psoriasis in the mouse model.
Biochimie, 123, 73-80.
Kharel, R. (2010). Indian traditional herbs
Adhatoda vasica and its Medicinal application.
J. Chem, 2(1), 240-245.
Kurd, S. K., Smith, N., VanVoorhees, A., Troxel, A. B., Badmaev, V., Seykora, J. T., & Gelfand, J. M. (2008). Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial.
Journal of the American Academy of Dermatology, 58(4), 625-631.
Li, W., Zhang, C., Du, H., Huang, V., Sun, B., Harris, J. P., ... & Kevil, C. G. (2016). Withaferin A suppresses the up?regulation of acetyl?CoA carboxylase 1 and skin tumour formation in a skin carcinogenesis mouse model.
Molecular carcinogenesis,
55(11), 1739-1746.
Mythilypriya, R., Shanthi, P., & Sachdanandam, P. (2007). Oral acute and subacute toxicity studies with Kalpaamruthaa, a modified indigenous preparation, on rats.
Journal of Health science, 53(4), 351-358.
Naira, N., Rohini, R. M., Syed, M. B., & Amit, K. D. (2009). Wound healing activity of the hydroalcoholic extract of
Ficus religiosa leaves in rats.
Internet J Altern Med,
6, 2-7.
Nirmala, A., Eliza, J., Rajalakshmi, M., Priya, E., & Daisy, P. (2008). Effect of hexane extract of
Cassia fistula barks on blood glucose and lipid profile in streptozotocin-diabetic rats.
International Journal of Pharmacology, 4(4), 292-296.
OECD, T. N. (1981). 410: Repeated Dose Dermal Toxicity: 21/28-day Study.
OECD Guidelines for the Testing of Chemicals, Section,
4.
Patwardhan, B. (1992). Ayurveda and future drug development. J. Altern. Complement.
Med., 19, 9-10.
Perveen, R., Naqvi, S. N. H., Azmi, M. A., Tariq, R. M., Ahmed, M., & Mehmood, S. (2008). Determination of mammalian toxicity of Cedrus deodara root oil, against albino rats (Wistar strain).
Pakistan Journal of Entomology.
Picrorhiza kurroa Monograph (2001).
Alternative medicine review, 6(3): 320-321.
Picrorrhiza root: Pharmacology (
http://www.mdidea.com/products/new/new04806.html). Accessed on 6th October 2020.
Prasad, D., & Rao, C. M. (1995). Wound healing profiles of ketorolac, metronidazole and tinidazole administered post-surgically.
Indian journal of experimental biology, 33(11), 845-847.
Project Code No. SSP-60 (1999), Industrial Toxicology Research Center, Council of Scientific and Industrial Research, Lucknow.
Rahman, M. S., & Anwar, M. N. (2007). Antimicrobial activity of crude extract obtained from the root of
Plumbago zeylanica.
Bangladesh Journal of Microbiology, 24(1), 73-75.
Saeedi, M., Morteza?Semnani, K., & Ghoreishi, M. R. (2003). The treatment of atopic dermatitis with liquorice gel.
Journal of Dermatological Treatment, 14(3), 153-157.
Saikia, A. P., Ryakala, V. K., Sharma, P., Goswami, P., & Bora, U. (2006). Ethnobotany of medicinal plants used by Assamese people for various skin ailments and cosmetics.
Journal of Ethnopharmacology, 106(2), 149-157.
Saha, S. A. N. T. A. N. U., & Subrahmanyam, E. V. S. (2013). Evaluation of the anti-inflammatory activity of ethanolic extract of seeds of
Holarrhena pubescens(Buch.-Ham.) Wall.
International Journal of Pharmacy & Pharmaceutical Sciences, 5, 915-919.
Saha, K., Mukherjee, P. K., Das, J., Pal, M., & Saha, B. P. (1997). Wound healing activity of
Leucas lavandulaefolia Rees.
Journal of Ethnopharmacology, 56(2), 139-144.
Sangita, D., Sarkar, P. K., Sengupta, A., & Chattopadhyay, A. A. (2008). Clinical study of Aragvadha (
Cassia fistula Linn.) on Vicharchika (Eczema). J. Res. Educ.
Indian Med, 27-32.
Sato, Y., Oketani, H., Singyouchi, K., OHTSUBO, T., KIHARA, M., SHIBATA, H., & HIGUTI, T. (1997). Extraction and purification of effective antimicrobial constituents of
Terminalia chebula RETS. against methicillin-resistant
Staphylococcus aureus.
Biological and Pharmaceutical Bulletin,
20(4), 401-404.
Sawarkar, H. A., Khadabadi, S. S., Mankar, D. M., Farooqui, I. A., & Jagtap, N. S. (2010). Development and biological evaluation of herbal anti-acne gel.
Int J PharmTech Res, 2, 2028-31.
Seok, C. H., Won, I., Kim, J. H., Kim, B. J., Kim, J. H., Heo, M. Y., & Kim, H. P. (1996). Biological screening of 100 plant extracts for cosmetic use (?) Inhibitory activities of tyrosinase and DOPA autooxidation. Presented at the 19th IFSCC Congress.
Simin, K., Ali, Z., Khaliq-Uz-Zaman, S. M., & Ahmad, V. U. (2002). Structure and biological activity of a new rotenoid from Pongamia pinnata.
Natural product letters, 16(5), 351-357.
Singha, P. K., Roy, S., & Dey, S. (2003). Antimicrobial activity of
Andrographis paniculata. Fitoterapia, 74(7-8), 692-694.
Shailajan, S., Yeragi, M., Matani, A., & Gurjar, D. (2013). VARIATION IN [Beta]-SITOSTEROL CONTENT FROM
CASSIA FISTULA L. FRUIT PULP COLLECTED FROM DIFFERENT GEOGRAPHICAL REGIONS.
International Journal of Pharmaceutical Sciences and Research, 4(11), 4392.
Shanbhag, T. V., Sharma, C., Adiga, S., Bairy, L. K., Shenoy, S., & Shenoy, G. (2006). Wound healing activity of alcoholic extract of
Kaempferia galanga in Wistar rats.
Indian J Physiol Pharmacol, 50(4), 384-390.
Shanbhag, T., Shenoy, S., & Rao, M. C. (2005). Wound healing profile of
Tinospora cordifolia.
Indian drugs, 42(4), 217-221.
Sharma, M., Levenson, C., Browning, J. C., Becker, E. M., Clements, I., Castella, P., & Cox, M. E. (2018). East Indian sandalwood oil is a phosphodiesterase inhibitor: A new therapeutic option in the treatment of inflammatory skin disease.
Frontiers in Pharmacology, 9, 200.
Shivhare, Y., Singour, P. K., Patil, U. K., & Pawar, R. S. (2010). The wound healing potential of methanolic extract of
Trichosanthes dioica Roxb (fruits) in rats.
Journal of Ethnopharmacology,
127(3), 614-619.
Sinha, S.C., (1996). Medicinal Plants of Manipur.
Mass & Sinha publications, Manipur, India, 172.
Smitha, G. N., Asif, A. K., Mukesh, S. S., & Geetanjali, S. S. (2010). Anti-inflammatory activity of
Pongamia pinnata stems bark in rats.
Journal of pharmacy research, 3(4), 828-830.
Srinivasan, K., Muruganandan, S., Lal, J., Chandra, S., Tandan, S. K., & Prakash, V. R. (2001). Evaluation of the anti-inflammatory activity of
Pongamia pinnata leaves in rats.
Journal of ethnopharmacology, 78(2-3), 151-157.
Subbaiah, K. V., & Savithramma, N. (2011). Bio-prospecting and documentation of traditional medicinal plants used to treat leprosy and eczema by ethnic groups of Kurnool district, Andhra Pradesh, India.
Journal of Pharmacy Research, 4(12), 4488-4490.
Sule A, Ahmed QA, Samah OA and Omar MN (2011). Bacteriostatic and bactericidal activities of
Andrographis paniculata extracts on skin disease-causing pathogenic bacteria.
Jo of Medicinal Plants Research 5(1): 7-14.
Svobodová, A. R., Galandáková, A., Šianská, J., Doležal, D., Ulrichová, J., & Vostálová, J. (2011). Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice.
Biological and Pharmaceutical Bulletin, 34(4), 471-479.
Swamy, H. K., Krishna, V., Shankarmurthy, K., Rahiman, B. A., Mankani, K. L., Mahadevan, K. M., ... & Naika, H. R. (2007). Wound healing activity of embelin isolated from the ethanol extract of leaves of
Embelia ribes Burm.
Journal of ethnopharmacology,
109(3), 529-534.
Tapsell, L. C., Hemphill, I., Cobiac, L., Sullivan, D. R., Fenech, M., Patch, C. S., ... & Fazio, V. A. (2006). Health benefits of herbs and spices: the past, the present, the future.
Tewari, U., Bahadur, A. N., Soni, P., & Pandey, S. (2014). Medicinal uses of some threatened species of wild herbal plants from Bilaspur District.
Indian J. Sci. Res, 4(1), 64-69.
Thas, J. J. (2008). Siddha medicine—background and principles and the application for skin diseases.
Clinics in dermatology,
26(1), 62-78.
The Ayurvedic Pharmacopoeia of India, Government of India Ministry of Health And Family Welfare Department of Indian System of Medicine & Homoeopathy, New Delhi, (2001): 47, 143.
Tiwari, A. K., Srinivas, P. V., Kumar, S. P., & Rao, J. M. (2001). Free radical scavenging active components from Cedrus deodara.
Journal of agricultural and food chemistry, 49(10), 4642-4645.
Uniyal, B. P., Singh, P. M., & Singh, D. K. (2002). Flora of Jammu and Kashmir.
Botanical Survey of India, Kolkata, 365.
Van der Fits, L., Mourits, S., Voerman, J. S., Kant, M., Boon, L., Laman, J. D., ... & Lubberts, E. (2009). Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.
The Journal of Immunology, 182(9), 5836-5845.
Wittmann, M., & Helliwell, P. S. (2013). Phosphodiesterase 4 inhibition in the treatment of psoriasis, psoriatic arthritis and other chronic inflammatory diseases.
Dermatology and therapy, 3(1), 1-15.
Xu, H., Fabricant, D. S., Piersen, C. E., Bolton, J. L., Pezzuto, J. M., Fong, H., ... & Constantinou, A. I. (2002). A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health.
Phytomedicine, 9(8), 757-762.
Zhao, T., Wang, X., Rimando, A. M., & Che, C. T. (1991). Folkloric medicinal plants:
Tinospora sagittata var. cravaniana and Mahonia bealei.
Planta Medica, 57(05), 505-505.
Zhou, L. L., Lin, Z. X., Fung, K. P., Che, C. T., Zhao, M., Cheng, C. H., & Zuo, Z. (2012). Ethyl acetate fraction of Radix rubiae inhibits cell growth and promotes terminal differentiation in cultured human keratinocytes.
Journal of Ethnopharmacology, 142(1), 241-247.